Arménio Coimbra Serra

armenio

Position:
Assistant Professor at University of Coimbra
Email address:
armenio.serra@gmail.com
Academic background:
  • PhD in Chemistry (specialty, Organic Chemistry) at Coimbra University (1998)
  • 1st Degree in Biochemistry at University of Coimbra (1986)
Publications:
Research articles:
“On the mechanism of carboxilic acid co-catalyst assisted metalloporphyrin oxidations”, A. M. d’A. Rocha Gonsalves, and A. C. Serra, J. Molec. Catalysis, A: Chemical, 168 , 2001, 25.
“Immobilised porphyrins in monoterpene photooxidations” Sónia M. Ribeiro, Arménio C. Serra, A. M. d A. Rocha Gonsalves, J. of Catalysis, 2008, 256, 331-337.
“In Vitro Photodynamic Activity of 5,15-bis(3-Hydroxyphenyl)porphyrin and its Halogenated Derivatives Against Cancer Cells”, Armenio Serra, Marta Pineiro, Catarina Isabel Santos, António Manuel d’A. Rocha Gonsalves, Margarida Abrantes, Mafalda Laranjo, Maria Filomena Botelho, Photochem. Photobiol. 2010, 86, 206-212.
“Controlled porphyrinogen oxidation for the selective synthesis of meso-tetraarylchlorins”, Arménio C. Serra, António M. d’A. Rocha Gonsalves, Tetrahedron Letters, 51, 2010, 4192-4194,
“[8π+2π] Cycloaddition of meso-Tetra- and 5,15-Diarylporphyrins: Synthesis and Photophysical Characterization of Stable Chlorins and Bacteriochlorins”, Nelson A. M. Pereira, Sofia M. Fonseca, Arménio C. Serra, Teresa M. V. D. Pinho e Melo and Hugh D. Burrows Eur. J. Org. Chem. 2011, 3970–3979.
 Patents:
Portuguese patent PT 102721- “Compostos Macrociclos Tetrapirrólicos com Rendimento Quântico de Oxigénio Singuleto Adequado à Terapia Fotodinâmica e processos para a sua Preparação”.  Inventors :António M. D’A. Rocha Gonsalves, Marta Pineiro, Arménio C. Serra.
European patent – “Tetrapyrrolic Macrocycles as Photodynamic Agents” EP 1472259B1. Inventors: António M. D’A. Rocha Gonsalves, Marta Pineiro e Arménio C. Serra.; Publication date: 02.09.09
International patent application PCT/EP2011/060256 “Macrocyclic tetrapyrrolic compound of the family of porphyrins, chlorins and bacteriochlorins as photosensitizers for photodynamic therapy” Inventors: António M. D’A. Rocha Gonsalves, Marta Pineiro, Arménio C. Serra, Filomena Botelho.
Portuguese patent (provisional patent application nº105267) “ Nonsteroidal anti-inflammatory drug conjugates with cyclodextrin: a microwave approach to the synthesis” Amélia Vieira, Arménio C. Serra, Rui A. Carvalho, Alexandra Gonsalves, Ana Figueiras, António Rocha Gonsalves, Francisco Veiga
European patent (provisional patent application nº11007013.3.) “ Nonsteroidal anti-inflammatory drug conjugates with cyclodextrin: a microwave approach to the synthesis” Amélia Vieira, Arménio C. Serra, Rui A. Carvalho, Alexandra Gonsalves, Ana Figueiras, António Rocha Gonsalves, Francisco Veiga
Papers in international scientific periodicals with referees:
“Radical Chain Cyclizations.  The Light Induced Addition of Tosyl Iodide and Tosyl Bromide to Diallyl Ether” Arménio C. Serra, Carlos M. M. da Silva Corrêa, Journal of Chemical Research (S) 1989, 85.
“Radical Chain Cyclizations of Allylic Compounds”, Arménio C. Serra, Carlos M. M. da Silva Corrêa, M. A. M. S. A. Vieira and M. A. Gomes (in part), Tetrahedron 1990, 46, 3061.
“An Interesting Rearrangement of Unsaturated Sulphonate and Thiosulphonate Esters”, Arménio C. Serra, Carlos M. M. da Silva Corrêa, Tetrahedron Letters 1991 32, 6653.
“The Effect of the Carbonyl Group in the Cyclization of 1-Hexenyl Radicals”, Arménio C. Serra, Carlos M. M. da Silva Corrêa, M. L. C. do Vale, Tetrahedron  1991, 47, 9463.
“5,10,15,20-Tetrakisaryl-and 2,3,7,8,12,13,17,18-octa-halogeno-5,10,15,20-tetrakis-arylporphyrins and their Metal Complexes as Catalysts in Hypoclorite Epoxidation”, Mariette M. Pereira, A. M. d´A. Rocha Gonsalves, Arménio C. Serra, R. A. W. Johnstone, M. Luisa P. G. Nunes, J. Chem. Soc. Perkin Trans I 1994, 2053.
“New Procedures for the Synthesis and Analysis of 5,10,15,20-Tetrakis (sulphophenyl)porphyrins and Derivatives Through Chlorosulphonation”, A. M. d´A. Rocha Gonsalves, R. A. W. Johnstone, M. M. Pereira, A. M. P. de SantAna, A. C. Serra, A. J. F. N. Sobral, P. A. Stocks, Heterocycles 1996, 43, 829.
“Improved Synthesis of 5,10,15,20-Tetrakis-Aryl and Tetrakis-Alkyl Porphyrins”, R. A. W. Johnstone, M. L. P. G. Nunes, M. M. Pereira, A. M. d´A. Rocha Gonsalves e A. C. Serra, Heterocycles 1996, 43, 1423.
“Sulphonamide porphyrins in the biomimetic oxidation by H2O2.  An efficient two-phase system”, A. M. d´A. Rocha Gonsalves. M. M. Pereira e A. C. Serra, Anales de Química Int. Ed. 1996, 92, 375.
“2,4-Dibromo-5-hydroxybenzaldehyde”, A. M. Beja, J. A. Paixão, M. R. Silva, L. Alte da Veiga, A. M. d´A. Rocha Gonsalves. M. M. Pereira e A. C. Serra, Acta Cryst.1997, C53, 494.
“Potassium 3-Formyl-2,4-dinitrophenolate Dihydrate” J. A. Paixão, A. M. Beja, M. R. Silva, L. Alte da Veiga, A. M. d´A. Rocha Gonsalves e A. C. Serra, Acta Cryst.1998, C54, 618.
“Crystal structure of 2,4,6-tribromo-5-hydroxybenzaldeyde, C7H3Br3O2”,  A. Matos Beja, J. A. Paixão, M. Ramos Silva, A. M. d’A. Rocha Gonsalves, M. M. Pereira e A. C. Serra, Zeitschrift fur Kristallographie- New Crystal Structures 1998, 213, 138.
“2,4,6-triiodo-3-hydroxybenzaldehyde”, A. Matos Beja, J. A. Paixão, M. Ramos Silva, L. Alte da Veiga, A. C. Serra and A. M. d’A. Rocha Gonsalves, Acta Crystal.,1999, C55,
“3-Hydroxybenzaldeyde”, J. A. Paixão, A. Matos Beja, , M. Ramos Silva, L.Alte da Veiga and A. C. Serra, Acta Crystal.,2000, C56, 1348.
“2-bromo-5-hydroxybenzaldeyde”, A. Matos Beja, J. A. Paixão, M. Ramos Silva, A. M. d’A. Rocha Gonsalves, and A. C. Serra, Acta Crystal., 2000, C56, 354.
“Metalloporphyrin catalytic oxidations of hydrocarbons by H2O2”, A. M. d’A. Rocha Gonsalves, and A. C. Serra, J. Porphyrin and Phthalocyanines, 2000, 4, 598.
“On the mechanism of carboxilic acid co-catalyst assisted metalloporphyrin oxidations”, , A. M. d’A. Rocha Gonsalves, and A. C. Serra, J. Molec. Catalysis, A: Chemical, 168 , 2001, 25.
“Oxidation of azo dyes in oil-in-water microemulsions catalysed by metalloporphyrins in presence of lipophilic acid”, M.Hager, K. Holmberg, A. M. d’A. Rocha Gonsalves and A. C. Serra, Colloids and surfaces  A: Physicochemical and Engineering Aspects, 2001, v 183-185, 247-251.
“Observations on the origin of phenylacetaldehyde in styrene epoxidation and the mechanism of oxidations catalysed by manganese complexes of porphyrins”, A. M. d’A. Rocha Gonsalves and Arménio C. Serra, J. C. Soc. Perkin Trans., 2002, 715-719.
“Low temperature matrix-isolation and solid state vibrational spectra of 5-chlorotetrazole”, Susana. C. S. Bugalho, A. C. Serra, M. Lurdes Cristiano and R. Fausto, Phys. Chem. Chem.Phys., 2002, 4, 1725-1731.
“Heavy atom effects on metalloporphyrin and polyhalogenated porphyrin”, Emilia G. Azenha, Arménio C. Serra, Marta Pineiro, Mariette M. Pereira, J. Seixas Melo, Luís G. Arnaut, Sebastião J. Formosinho, A. M. d’A. Rocha Gonsalves, Chemical Physics 280 2002 177-190.
“A view on the mechanism of metalloporphyrin degradation in hydrogen peroxide epoxidation reactions”, A. C. Serra, E. C. Marçalo and A. M. A. Rocha Gonsalves, Journal Molecular Catalysis A, 215 2004, 17-21.
“Efficient azo dye degradation by hydrogen peroxide oxidation with metalloporphyrin as catalyst” Arménio C. Serra, Cristina Docal and A. M. D’ A. Rocha Gonsalves, Journal Molecular Catalysis A, 238 2005, 192-198.
“Covalently immobilized porphyrins as photooxidation catalysts” Sónia M. Ribeiro, Arménio C. Serra;, A. M. d A. Rocha Gonsalves, Tetrahedron, 2007,63,7885.
“Immobilised porphyrins in monoterpene photooxidations” Sónia M. Ribeiro, Arménio C. Serra;, A. M. d A. Rocha Gonsalves, J. of Catalysis, 2008, 256, 331-337.
“Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin”, A.C. Serra, M. Pineiro, A.M.d’A. Rocha Gonsalves,, M. Abrantes, M. Laranjo, A.C. Santos, M.F. Botelho, Journal of Photochemistry and Photobiology B: Biology, 2008, 92  61–67.
“A look on Clinical Applications and developments on Photodynamic Therapy”, Arménio Serra, Marta Pineiro, Nelson Pereira, António Rocha Gonçalves, Mafalda Laranjo, Margarida Abrantes, Filomena Botelho, Oncology Reviews,2008, 2, 235-249.
Approaches to a broad range of high performance PDT sensitizers, António. M. d. A. Rocha Gonsalves, Arménio C. Serra, Marta Pineiro and M. Filomena Botelho, Reporters, Markers, Dyes, Nanoparticles and Molecular Probes for Biomedical Applications, Edited by S. Achilefu, R. Raghavachari, Proceedings of the SPIE, 2009, Vol. 7190, 719005-10.
“State of Research Tracks and Property Protection of Photodynamic Sensitizers and Delivery Methodologies”, Marta Pineiro, Arménio C. Serra and António M. d’A. Rocha Gonsalves, Recent Patents on Chemical Engineering, 2009, 2, 98-122.
“The small stones of Coimbra in the huge tetrapyrrolic chemistry building”, António M.d’A. Rocha Gonsalves, Arménio C. Serra and Marta Pineiro, J. Porphyrins Phthalocyanines 2009; 13: 429–445.
“In Vitro Photodynamic Activity of 5,15-bis(3-Hydroxyphenyl)porphyrin and its Halogenated Derivatives Against Cancer Cells”, Armenio Serra, Marta Pineiro, Catarina Isabel Santos, António Manuel d’A. Rocha Gonsalves, Margarida Abrantes, Mafalda Laranjo, Maria Filomena Botelho, Photochem. Photobiol. 2010, 86, 206-212.
“The influence of the support on the singlet oxygen quantum yields of porphyrin supported photosensitizers”, Marta Pineiro, Sónia M. Ribeiro, and Arménio C. Serra*, ARKIVOC 2010,(v), 51-63.
“Photodynamic therapy on bladder cancer cells: Further studies on the performance of Coimbra sensitizers” António M. d’A. Rocha Gonsalves, Arménio C. Serra, Marta Pineiro, and M. Filomena Botelho, Proc. SPIE 7715, 77151N (2010)
“Synthesis of new naphthoquinone-containing pyrrolo-thiazoles and evaluation of the antiproliferative activity”, Susana M. M. Lopes, Mafalda Laranjo, Arménio C. Serra, Ana M Abrantes, António M. d’A. Rocha Gonsalves, M. Filomena Botelho, Ana M. Beja, Manuela R. Silva, Teresa M. V. D. Pinho e Melo, Jounal of Heterocyclic Chemistry, 2010, vol. 47(4): 960-966.
“Synthetic porphyrins bearing β-propionate chains as photosensitizers for photodynamic therapy”,  N. Pereira, A.C. Serra, M. Piñeiro, A.M. Rocha-Gonsalves, M. Abrantes, M. Laranjo, M.F. Botelho Journal of Porphyrins and Phthalocyanines 2010; vol. 14(5): 438-445.
“Controlled porphyrinogen oxidation for the selective synthesis of meso-tetraarylchlorins”, Arménio C. Serra, António M. d’A. Rocha Gonsalves, Tetrahedron Letters, 51 (2010) 4192-4194,
“Covalently immobilized porphyrins on silica modified structures as photooxidation catalysts”, Sónia M. Ribeiro, Arménio C. Serra, A.M.d’A. Rocha Gonsalves. Journal of Molecular Catalysis A: Chemical, 326 (2010)121-127.
“Novel Approach to Chlorins and Bacteriochlorins: [8π+2π] Cycloaddition of Diazafulvenium Methides with Porphyrins”, Nelson A. M. Pereira, Arménio C. Serra, and Teresa M. V. D. Pinho e Melo, Eur. J. Organic Chemistry (2010), 6539–6543.
“Photosensitizers for photodynamic therapy:One pot heterogeneous catalytic transfer reduction of porphyrins”, Amadeu F. Brigas, Ana M. Rosa da Costa, Arménio C. Serra, Catarina Pires, Journal of Pharmacy And Bioallied Sciences (2011), 3, 294-297.
“Silica grafted polyethylenimine as heterogeneous catalyst for condensation reactions”, Sonia M. Ribeiro, Arménio. C. Serra, A.M. d’A. Rocha Gonsalves, Applied Catalysis A: General 399 (2011) 126–133
“[8π+2π] Cycloaddition of meso-Tetra- and 5,15-Diarylporphyrins: Synthesis and Photophysical Characterization of Stable Chlorins and Bacteriochlorins”, Nelson A. M. Pereira, Sofia M. Fonseca, Arménio C. Serra, Teresa M. V. D. Pinho e Melo, Hugh D. Burrows, Eur. J. Org. Chem. (2011) 3970-3979.
“Mild oxygen activation with isobutyraldehyde promoted by simple salts”, Arménio C. Serra, António M. d’A. Rocha Gonsalves, Tetrahedron Letters 52 (2011) 3489–3491.
“Ambient Temperature Rapid ATRP of Methyl Acrylate, Methyl Methacrylate and Styrene in Polar Solvents with Mixed Transition Metal Catalyst System”, Patrícia V. Mendonça, Arménio C. Serra, Jorge F. J. Coelho, Anatoliy V. Popov, Tamaz Guliashvili, Eur. Polym. J. (2011), 47, 1460.
“A Nonionic Porphyrin as a Noninterfering DNA Antibacterial Agent”, Sónia Mendes, Fábio Camacho, Tito Silva, Cecília R. C. Calado, Arménio Coimbra Serra, António M. d’A. Rocha Gonsalves and Mónica Roxo-Rosa, Photochem. Photobiol. (2011), 87, 1395-1404.